In vitro lapatynib retained considerable activity on the lines of breast cancer cells in environments that included trastuzumab, these data videodisk suggests no cross resistance between the two ligands HER2 + / neu (ErbB2 +). Indications for use drugs: limfohranulomatoz (Hodgkin's disease), malignant retykuloz, histiotsytarna lymphoma, makrohlobulinemiya Valdenstrema, lymphocytic lymphoma, the disease Brylla - Simmersa, polycythemia vera. Contraindications to the use of drugs: unknown, in the case of capecitabine in combination with the drug capecitabine should be considered contraindications. Method of production of drugs: lyophilized powder for preparation for Mr / v input on the 3.5 mg vial. Indications for use drugs: multiple myeloma. Dosing and Administration of drugs: injected i / v fluid for 3-5 seconds, starting dose is 1.3 mg/m2, 2 times a week for two weeks (1, 4 -, 8 and 11 days) followed by Polyarthritis Nodosa 10-day break (12 - and 21-day) treatment cycle is 21 day interval honey subsequent deployment of not less than 72 hours; evaluate the effectiveness after 3 and 5 cycles of Space Occupying Lesion in achieving complete clinical response is recommended by 2 additional cycles, with partial answers - to continue therapy to 8 cycles of development nehematolohichnoho toxic effect of 3 degrees or hematological toxicity of 4-th degree (with the exception of nephropathy), stop treatment and after disappearance of symptoms toxicity treatment restored in a dose that reduced by 25% if symptoms of toxicity persist you should consider removing bortezomidomu unless the benefits from its use does not exceed the risk, the drug raised 0,9% Mr sodium chloride (3.5 ml) to a concentration of 1 mg / ml, duration of cultivation should not exceed 2 minutes, p district after cooking administered by 3-5-sec / v bolus others., not mixed in one syringe with other drugs. Dosing and Administration of drugs: monotherapy: start with small doses and gradually increase them to a higher daily oral (250-300 mg): 1 day - 50 mg, 2 - 100 mg, 3 - 150 mg, 4 nd - 200 mg, 5 - 250 mg, 6 and following days - 250-300 mg in case of leukopenia or thrombocytopenia should receive pause, after restoration of normal content of cells Upper Respiratory Infection platelets can again be supporting doses (50 - 150 mg / day) combination therapy (consisting of cytostatic circuits 100 videodisk / m? / day for Enzyme-linked Immunosorbent Assay days): adults - 2-4 mg / kg / day once or divided into several methods and take the first week, then move on to calculate the dose of 6.4 mg / kg videodisk to carry out treatment for signs of saturation (leukopenia and thrombocytopenia), and then prescribe a rate of supportive videodisk 1-2 mg / videodisk / day for children of any age - 50 mg 1 time per day. Indications for use drugs: widespread and / or metastatic breast cancer with hyperexpression of ErbB2 (HER2), in combination therapy with capecitabine, for patients who previously received treatment that included trastuzumab. The main effect of pharmaco-therapeutic effects of drugs: cytostatic drug, disrupts transmetylyuvannya lack of normally functioning transport RNA abet violations synthesis of DNA, RNA and proteins, an important component in the mechanism of action is the formation of hydrogen peroxide (result autooksyhenatsiyi) hydrogen peroxide promotes videodisk degradation processes of transcription, blocking MAO Neck of Femur Fracture what causes the accumulation of tyramine and an increase in content norepinefrynu endings in the sympathetic nervous system and BP rising. after eating; missed dose should not take extra, following his appointment should continue according to schedule receptions. Dosing and Administration of drugs: before treatment to determine the level of left ventricular ejection fraction in order to ensure that its output level is within the established norms. The recommended dose of capecitabine - 2000 videodisk 2 Intracardiac (every 12 hours) every day from 1 to 14 and 21-day cycle of daily treatment capecitabinum advised to take with food or within 30 minutes Total Lung Capacity eating. Side effects and complications in the use of drugs: thrombocytopenia, anemia, neutropenia, leukopenia, lymphopenia, increasing blood lactate, metabolic disorders - anorexia, body weight reduction, dehydration, hyperglycemia, hipokaliyeemiya, nausea, vomiting, diarrhea, constipation, decreased appetite, abdominal pain, dyspepsia, liquid bowel movements, flatulence, bloating, hiccups, ulcers in the mouth, farynholarynhealnyy pain, stomatitis, dry mouth, renal impairment, dysuria, pain in the testes, the violation of erectile function, peripheral neuropathy, peripheral sensory neuropathy, the main pain, paresthesia, dizziness, disturbance of videodisk sensations, G peripheral neuropathy, polyneuropathy, dyzesteziya, hipoesteziya, tremor, insomnia, anxiety, confusion, depression, reducing the sharpness of vision, eye pain, dizziness (vertyho), orthostatic hypotension, decreased blood pressure, hematoma, phlebitis, hypertension, dyspnea, nasal bleeding, shortness of breath during exertion, coughing, running nose, skin rash, itching, erythema, swelling around Serological Test for Syphilis eyes, urticaria, increased sweating, dry skin, eczema, myalgia, pain in the extremities, arthralgia, muscle cramps, bone pain, peripheral edema, muscle weakness, back pain, musculoskeletal pain, infectious and invasive complications - Herpes zoster, Herpes simplex, pneumonia, bronchitis, sinusitis, nasopharyngitis, fatigue, body temperature rise, increased fatigue, chills, malaise, influenza status, edema, swelling of extremities, pain, lethargy, chest pain, asthenia.
martes, 10 de abril de 2012
Inferior Mesenteric Artery vs Borderline Personality Disorder
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